Projects

Crowdacure is preparing to campaign for 5 research projects, 

all being hard to fund or in underfunded areas of medical research. The projects are currently in peer-review hence they are not yet confirmed.

As soon as they are approved by the experts we will let you know in what fields is the research.

However, you will still need to be patient as we will work with them in taking the scientific material and make it easy to understand for all.

Last year, 2 research projects have campaigned with Crowdacure.

The first is a research project in multiple sclerosis ran by Prof Gavin Giovannoni, Prof Julian Gold and Dr David Holden (see below). 

The second is a project in managing phantom limb pain with augmented reality lead by Professor Ali Mousavi (see below). The latter campaign has been interrupted to join the new campaign we are preparing.

You can see the completed multiple sclerosis campaigns below, and the phantom limb pain campaign, which is on hold.

 

Thank you to the donors!

Aidan McGilly
Alan Davis
Alan lafferty
Alberto Leonardi
Amy Taylor
Anne-Louise Grant
Anneline Nordvik
Anthony Buckley
Antony Michael grace
Astryd Jamieson
Brad Will
Brian James Malyon
Carlos Ollero Sánchez
Carol Crooks
Caroline Birch
Caroline Lafferty
Catherine complin
caze guillaume
Charlie Davie
Chris Barrowcliff
christian van der ree
Christina Fitzsimons
Christo Albor
Clara Brighton
Cynthia Samford

Dan Baker

Daniele Carassiti

Darin Allan

David Grimsdell

David hewlett

Debbie Hawkes

Jackie Brett
Jackie Harding

James Mayer

Jan Baranski

Jane Black

Janka Petocz

Javier Navarro Martínez

Jenny Macken

Jiri Doubekjo maclean

John Wiltshire

Jonathan Mark Massheder

Juan Pardo-Montero

JULIE GOULD

Judy Beveridge

Judy Cornish

Julia Gold

Juliet solomon

Kaela Jamieson

Katherine Minden

Katie Street

Kayvan Mirshahi

Klaus Schmierer

Laura Kolaczkowski
Linda McLean
Lisa Gowland
luca
Lucy Highland
Magda issmer
Marc
marc stecker
Margaret Drysdale


Debbie Scott
Debra Singer
Debra Smith
Denise Winser
Dominique Giovannoni
Duncan Long
Edward polito
Eemeli Kantola
Elise Nørrekjær
Emma treby
Eva Mazariegos
Fabrizio Fracassi
Fiona Grady
Fiona Heather-O'Leary
Fiona Pain
Frank Pleyer
Gary Faulkner
George Pepper
Gill Martin

Goldberg Bellina

Grant Adamson

Hamish McCracken
Harriet Mackintosh
Harvey sampson
Helen Scott
Helle Kirstine Rosenmeier
Henrik L
Iain Cameron
Inga Bergen

Jacqueline Cosgrave

Maria Garcia

Marianne kasti

Mark Baker

Mats Lundström

Maureen Cawte

Merritt Robinson

Michael Bray

Michelle Crowson
Miles Laddie
Milton Guerreiro
naomi harris
Nonita Thomas
Nurit pollak
Olivier Van Der Meeren
PETER MCGILLY
Pamela Qaddourah
Pat O'Hara
Patricia Lockhart
Patrisha Rudd
Paul Steiner
Prilly Meyer
Richard Rosch
Richard William Stoner
Robert Morgan
Roisin Ni Thuama
Rolland Myers
Romain
Ronald Jamieson
Russell Johnson Kyle
Samantha Rayner
Samia Gaskell

Sarah Webley
Sheila Peterson
Simon Carr
Simon Dobinson
susan Leung
Stig Granfors
Sue Niekirk
Susan Doumbos
Susan Rutherford
Susan Stenton
TARUN MALIK
Tessa Reid
Thomas Nolan
Tony Bernauer
Tracy Doust
Tracy Whiteaker
Treasa Anderson
Tuvia Rosenthal
vipra khanna malik
Vivienne Pollock
William Keller
William Wallace
Xuenong Bo
Zak Mallen

The problem

 

Multiple sclerosis is a severely disabling disease affecting two million people around the world.1 None of the available therapies can stop the disease’s progression.2

Our solution

 

Multiple sclerosis might not just be an autoimmune disease. Viruses could participate in causing the disease. Help us find out if we can treat multiple sclerosis with antiviral drugs.

We will use Famciclovir

 

This generic drug has shown to reduce the activity of the Epstein-Barr virus. It has been administered to a small number of people with severe infectious mononucleosis. Compared to other available drugs we think it’s safer, cheaper and better tolerated.

It is very difficult to treat viruses.

 

Viruses are not alive, so they can’t be ‘killed’. We want to make sure the Famciclovir treatment reduces the activity of the virus. To do this we’ll compare how much of the virus is present before and after treatment.

 

 

 

 

 

 

 

 

 

 

What’s the best time of day to detect the virus?

 

We know we can detect the virus in saliva, but we don’t yet know how much virus is found in the saliva of people with MS, or when is the best time of day to detect it. The first step of our project is to find this out.

 

 

 

 


 

The experiment

 

Measuring the presence of the EBV virus by

Take saliva samples to measure the virus

 

 

 

 

 

 

 

Make the virus DNA visible using polymerase chain reaction
 

 

 

 


PCR

Read and analyse the data

 

 

 

 

 

 

 

 

The Centre for Sport and Exercise Science at Sheffield Hallam University have recently conducted research on people with multiple sclerosis (Carter et al., 2014). As part of this research, they collected saliva samples from 120 people and have kindly shared them with us*.

 

We will measure how much viral DNA we find in the collected saliva samples from each patient at 8 am, 12 pm, 5 pm and 9 pm on the collection days. It’s possible that the presence of the virus DNA will vary throughout the day. The virus presence may not be stable over time.

 



*Ethical approval has already been obtained from the South Yorkshire Research Ethics Committee to analyse these samples.

 

Why are we measuring the EBV virus?

 

Every adult with multiple sclerosis has been infected with the Epstein-Barr virus at some point in their life and we want to discover its role in potentially causing the MS disease to develop.

 

The Epstein-Barr virus is well-known for causing the ‘kissing disease’ (infectious mononucleosis) and we know that if a person has had infectious mononucleosis as a teenager they are more likely to get multiple sclerosis as an adult.


 

Our goal

 

We want to know what time of day to measure the presence of the virus, and how high the virus level is in patients before they start the treatment. We aim to have this information within three months. We will use our findings to design a pilot study on people with multiple sclerosis to see the effect of Famciclovir on the Epstein-Barr virus.


 

Why is this research hard to fund?

 

Private sector funding bodies generally do not give finance to projects that use a generic drug such as Famciclovir. In addition, viral hypothesis regarding multiple sclerosis is an alternative direction of research, with the main working hypothesis being autoimmunity. As this is a slightly unconventional approach it is harder to gather the necessary support and funding.


 

Thank you!

 

Thank you so much for partnering with us to make this project happen. Check back soon for updates on our progress. We hope to be able to share the results with you three months after the end of this campaign.

 

If you want to send your feedback to the research team you can leave a comment or email them at gavin.giovannoni@crowdacure.com.

 

 

 

A Proper Treatment for Phantom Limb Pain

Phantom Limb Pain affects 8 million amputees worldwide, with 2.5 million of these suffering a severe form of this agonising pain. Despite the number of sufferers, funding to advance medical research in phantom limb pain is insufficient, leaving them with no satisfying treatment.

 

 

 

 

 

 

What is Phantom Limb Pain 

Phantom Limb Pain is an agonising and ongoing pain for as many as 8 million amputees worldwide – affecting patients who have lost a limb or part of the body to diabetes, cancer, infections, wars, accidents and electrocutions.

 

 

 

 

 

 

 

 

A nervous system disorder, symptoms of Phantom Limb Pain can include painful sensations of stabbing and electric shocks in the area where the limb was lost.

Even when limbs are replaced by prosthetics, many continue to suffer from the pain because the brain hasn’t accepted either the loss of the old and the replaced limb.

NOW Pioneering research led by Professor Ali Mousavi at Brunel University and Professor Jonathan Cole from Poole Hospital in the UK propose to advance virtual reality-based solutions that will deliver effective, personalised and accessible treatment for sufferers. Prof Ali Mousavi needs your support to help advance this research to change amputees’ lives forever. This is why he asked we help him to fundraise. Together you are putting research for a better treatment for phantom limb pain on the agenda.

 

This campaign has raised to date £2,019 from 42 pledgers 

It is on hold to join the pooled campaign end of 2017

For any information please do not hesitate to contact

Dr Sagit Weiss at sagit@crowdacure.com